As Abraham Zapruder's granddaughter, Alexandra explained in her memoir, the impact of the film on the family hasn't been great. They avoided talking about it, trying to just be a normal family. With their name being as recognizable as it was, though, people would ask questions, which left them to try and politely shut down any of those conversations. Plus, they've basically had to continuously deal with legal and financial details of the film and its ownership.
Decades and extensive legal issues later, an arbitrator demanded $16 million for the family, saying that the Zapruders still owned the film, but that the government had taken in from them; of course, the rest of the public had to have their say, with people suddenly trying to weigh in on things like their moral character (via The Miami Herald). To people looking in from the outside, it just looked like greed, like the family was trying to profit from tragedy.
That wasn't true at all, though. Abraham Zapruder had actually been really uncomfortable with that idea from the start, and the family later set such a high price because they had hoped the government would just drop it, allowing the film to stay in the National Archives, "where people could see it but it couldn't be mass-marketed." Obviously, things didn't go that way, and the media had a field day trying to drag their name through the mud.
